Publications

Recent Reviews

Molecular Immunology

Complement In The Brain
Veerhuis R, Nielsen HM, and Tenner AJ

 

CNSDI Magazine Cover Central Nervous System Diseases and Inflammation
The Complement System in the CNS: Thinking again
Andrea J. Tenner
and Karntipa Pisalyaput

 

Magazine coverComplement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions.
Bohlson SS
, Fraser DA, Tenner AJ.

 

Publications 1972 to 2012

  1. Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner AJ. C1q-induced LRP1B and GPR6, expressed early in AD mouse models, are essential for the C1q-mediated protection against amyloid beta (Aβ) neurotoxicity. J Biol Chem. 2013 [Epub ahead of print]
  2. Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman CW. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation. 9:179. 2012
  3. Benoit ME, Clarke EV, Morgado P, Fraser DA, Tenner AJ. Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol. 188(11):5682-93. 2012
  4. Linnartz B, Kopatz J, Tenner AJ, Neumann H. Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia. J Neurosci. 32(3):946-52. 2012
  5. Veerhuis R, Nielsen HM, Tenner AJ. Complement in the brain. Mol Immunol.  (14):1592-603. 2011
  6. Benoit ME, Tenner AJ. Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J Neurosci. 231(9):3459-69. 2011
  7. Fonseca MI, Chu SH, Berci AM, Benoit ME, Peters DG, Kimura Y,   Tenner AJ. Contribution of complement activation pathways to   neuropathology differs among mouse models of Alzheimer’s disease. J Neuroinflammation. 8(1):42011
  8. Fraser DA, Tenner AJ. Innate immune proteins C1q and  mannan-binding lectin enhance clearance of atherogenic lipoproteins by human  monocytes and macrophages. J Immunol. 185(7):3932-9. 2010.
  9. Zekavat G,  Mozaffari R, Arias VJ, Rostami SY, Badkerhanian A, Tenner AJ, Nichols KE, Naji  A, Noorchashm H. A novel CD93  polymorphism in non-obese diabetic (NOD) and NZB/W F1 mice is linked to a CD4+  iNKT cell deficient state. Immunogenetics. 62(6):397-407. 2010.
  10. Ager RR, Fonseca MI, Chu SH, Sanderson SD,  Taylor SM, Woodruff TM, Tenner AJ.
    Microglial C5aR (CD88) expression correlates with  amyloid-beta deposition in murine models of Alzheimer’s disease. J Neurochem. 113(2):389-401.2010.
  11. Fraser DA,  Pisalyaput K, Tenner AJ. C1q enhances  microglial clearance of apoptotic neurons and neuronal blebs, and modulates  subsequent inflammatory cytokine production. J Neurochem. 112(3):733-43. 2010.
  12. Fraser DA, Laust  AK, Nelson EL, Tenner AJ. C1q  differentially modulates phagocytosis and cytokine responses during ingestion  of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol. 183(10):6175-85. 2009.
  13. Woodruff TM,  Ager RR, Tenner AJ, Noakes PG, Taylor SM. The role of the complement system and  the activation fragment C5a in the central nervous system. Neuromolecular Med. 12(2):179-92. 2009.
  14. Fonseca MI, Ager RR, Chu SH, Yazan O, Sanderson SD, LaFerla FM,   Taylor SM, Woodruff TM, Tenner AJ.Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer’s disease.  J   Immunol. 183(2):1375-83, 2009
  15. Klos A, Tenner AJ, Johswich KO, Ager RR, Reis ES, Köhl J. The role of the anaphylatoxins in health and disease. Mol Immunol. 2009
  16. Zhou,  J., Fonseca,, M.I.,  Pisalyaput,  K. and Tenner, A.J. Complement C3 and C4 expression in murine mouse  models of Alzheimer’s Disease. J.  Neurochem. 106: 2080-2092, 2008.
  17. Alexander,  J.J., Anderson A.J., Barnum S.R., Stevens B., Tenner A.J., The Complement  Cascade: Yin-yang in Neuroinflammation: Neuro-protection and –degeneration. J.  Neurochem.107:1169-87, 2008.
  18. Li,M.,  Ager, R.R., Fraser, D.A., Tjokro, N.O. and Tenner, AJ.,  Development of a Humanized C1q A Chain  Knock-in Mouse:  Assessment of Antibody  Independent ß-Amyloid Induced Complement Activation. Mol. Immunol. 45:3244-3252, 2008.
  19. Lillis, A.P., Greenlee, M.C., Mikhailenko, I., Pizzo, S.V., Tenner, A.J.,   Strickland, D.K.and Bohlson, S.S.  The low-density lipoprotein receptor-related   protein (LRP/CD91) is not required for the C1q-triggered enhancement of   phagocytosis in murine macrophages.  J.Immunol. 181:364-373, 2008.
  20. Fraser, D.A. and Tenner, A.J. Directing an appropriate immune response: The role of defense collagens and   other soluble pattern recognition molecules. Current Drug Targets. 9(2), 2008.
  21. Pisalyaput, K. and Tenner, A.J., Complement component C1q inhibits β-amyloid and serum amyloid P induced neurotoxicity via caspase and calpain-independent mechanisms.  J. Neurochem. 104(3):696-707, 2008.
  22. Tenner, A.J. and  Pisalyaput, K., “The Complement System in the CNS:  Thinking again.” In Neuroinflammation and Disease, Eds: Thomas E. Lane, Monica Carson, Connie Bergmann, Tony Wyss-Coray, Springer, (Invited Review), In Press, 2007.
  23. Fraser, D.A.,  Arora, M., Bohlson, S.S., Lozano, E., and Tenner, A.J., Generation of Inhibitory NFkB complexes and pCREB correlates with the anti-inflammatory activity of complement protein C1q in human monocytes. J. Biol. Chem. 282:7360-7367, 2007.
  24. Bohlson, S.S., Fraser, D.A., and Tenner, A.J.  Complement Proteins C1q and MBL are Pattern Recognition Molecules that Signal Immediate and Long Term Protective Immune Functions.  Mol. Immunol. 44:33-43, 2007.   (Invited Review)
  25. Chong, Y.H., Shin, Y.J., Lee, E.O., Kayed, R., Glabe, C.G., and Tenner, A.J. ERK1/2 activation mediates oligomeric ABeta-induced neurotoxicity via caspase-3 activation and Tau cleavage in rat organotypic hippocampal slice cultures. J. Biol. Chem.281:20315-20325, 2006.
  26. Tenner, A.J. and Fonseca, M.I. The Double Edged Flower:  Roles of Complement Protein C1q in Neurodegenerative Diseases, Book Chapter, Advances in Experimental Medicine and Biology, Lambris, J.D. (Ed.), Springer, Vol. 586: 153-176, 2006.
  27. Fraser, D.A., Bohlson, S.S., Jasinskiene, N., Rawal, N., Palmerini, G., Ruiz, S., Rochford, R., and Tenner, A.J., C1q and MBL, components of the innate immune system, influence monocyte cytokine expression, J. Leuk. Biol. 80:107-116, 2006.
  28. Osmers, I., Szalai, A. J., Tenner, A.J., and Barnum,  S.R. Complement in BuB/BnJ Mice Revisited: Serum C3 Levels and Complement Opsonic Activity are Not Elevated, Mol. Immunol. 43:1722-5. 2006.
  29. Zhou, J., M. I. Fonseca, R. Kayed, S. D. Webster, I. Hernandez, O.Yazan, D. H. Cribbs, C.G. Glabe, and A. J. Tenner, Novel Aß peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer’s Disease,  J. Neuroinflammation 2:28, 2005.
  30. Bohlson, S.S., Silva, R., Fonseca, M. and Tenner, A.J.  CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma, J. Immunol.175:1239-1247, 2005.
  31. Fan, R. and Tenner, A.J.  Differential regulation of Aß42-induced neuronal C1q synthesis and microglial activation.  J. Neuroinflammation 2: 1-13, 2005.
  32. Zhang, M., Bohlson, S. S., Dy, M., and Tenner, A.J. Modulated Interaction of ERM protein, Moesin, with CD93. Immunology 115:63-73, 2005.
  33. Bohlson, S.S., Zhang, M., Ortiz, C.E. and Tenner, A.J.  CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis  J. Leuk. Biol. 77: 80-89, 2005.
  34. Li,M., Pisalyaput, K., Galvan, M., and Tenner, A.J.,  MCSF and IFN Trigger Distinct Mechanisms for Augmentation of Aß-Induced Microglia Mediated Neurotoxicity, J. Neurochem. 91:623-633, 2004.
  35. Fonseca, M.I., Zhou, J., Botto, M., and Tenner, A.J.  Absence of Complement protein C1q leads to less neuropathology in transgenic mouse models of Alzheimer’s Disease., J. Neuroscience 24: 6457-6465, 2004.
  36. Fonseca, M.I,, Kawas, C.H., Troncoso, J.C., and Tenner, A.J.,  Neuronal localization of C1q in preclinical Alzheimer’s Disease.  Neurobiology of Disease 15:40-46, 2004.
  37. Fan, R. and Tenner, A.J., Complement C1q expression induced by A beta in rat hippocampal organotypic slice cultures.  Exp. Neurology 185:241-253, 2004.
  38. Maruyama, H., Galvan, M., Waffarn, F., and Tenner, A. J., Human cord blood leukocyte innate immune responses to defense collagens.  Ped. Research 54:724-731, 2003.
  39. Park, M., Tenner, A. J., Cell Surface Expression of C1qRP/CD93 is Stabilized by O-Glycosylation. J. Cell. Physiol.  196:512-522, 2003.
  40. Danet, G. H., Luongo, J., Butler G., Lu, M. M., Tenner, A. J., Simon, M. C., Bonnet, D. A., C1qRp defines a new human stem cell population with haematopoietic and hepatic potential. PNAS 99: 10441-10445, 2002.
  41. Tenner, A. J.  Complement in Alzheimer’s Disease:  Opportunities for Modulating Protective and Pathogenic Events. Neurobiology of Aging, 22:849-861, 2001.
  42. Jack, D. L., Read, R. C., Tenner, A. J., Frosch, M., Turner, M. W., Klein, N. J., Mannose-binding  lectin regulated the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B. J. of Infectious Diseases 184: 1152-1162, 2001.
  43. Arora, M., Munoz, E., Tenner, A. J.,  Identification of the site on MBL critical for triggering enhancement of Phagocytosis.   J. Biol. Chem. 276: 43087-43094, 2001.
  44. Tenner, A.J. and Webster, S.D., Complement-mediated injury and inflammation in the pathogenesis of Alzheimer’s Disease. Book chapter, in Inflammatory Events in Neurodegeneration, S.C. Bondy and A. Campbell, ed, Prominent Press, Scottsdale, AZ, pp. 120-138, 2001.
  45. Webster,S.D., Galvan, M.D.,Ferran, E., Garzon-Rodriguez, W., Glabe, C.G., Tenner, A.J.,  Antibody-mediated phagocytosis of Aβ in microglia.  J. Immunol., 166:7496-7503, 2001.
  46. Head, E., Azizeh, B.Y., Lott, I.T., Tenner, A.J., Cotman, C.W. and Cribbs, D.H., “Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down syndrome”.  Neurobiology of Disease, 8: 252-265, 2001.
  47. Fonseca, M.I., Carpenter, P.M., Park, M.P., Palmarini, G. Nelson, E. L. and Tenner, A.J.  C1qRP, a myeloid receptor in blood, is predominantly expressed on endothelial in human tissue.  J. Leukoc. Bio. 70:793-800, 2001.
  48. Matsuoka, Y., Picciano, M., Malester, B., LaFrancois, J., Zehr,C., Daeschner, J.M., Olschowka, J.A., Fonseca, M.I., O’Banion, K.M., Tenner, A.J., Lemere, C.A., Duff, K.  Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer’s Disease.  Am. J. Path., 158: 1345-1354 2001.
  49. Yokota, T., Oritani, K., Takahashi, I., Ishikawa, J., Matsuyama, A., Ouchi, N., Kihara, S., Funahashi, T., Tenner, A.J., Tomiyama, Y., and Matsuzawa, Y.  Adiponectin, a novel member of soluble defense collagens, negatively regulates the growth of myelo-monocytic progenitors and the functions of macrophages.  Blood, 96:1723-1732, 2000.
  50. Kim, T.S., Park, M., Nepomuceno, R.R., Palmarini, G., Winokur, S., Cotman,C. A., Bengtsson, U., Tenner, A.J.   Characterization of the murine homolog of C1qRP:  Identical cellular expression pattern, chromosomal location and functional activity of the human and murine C1qRP .  Mol. Immunol.  37: 377-389, 2000.
  51. Azizeh, B.Y., Head, E., Ibrahim, M.A., Torp, R., Tenner, A.J., Kim,R., Lott, I.T., and Cotman, C.W., Molecular dating of senile plaques in the brains of individuals with Down Syndrome and in Aged Dogs. Experimental Neurology 163:111-122, 2000.
  52. Eggleton, P., Tenner, A.J., Reid, K.B.M., C1q Receptors, Clin. Exp. Immunol.  120: 406-412, 2000.
  53. Webster, S.D., Yang, A., Margol, L., Glabe, C.G., and Tenner, A.J.  Complement component C1q modulates the phagocytic  behavior of microglia.  Experimental Neurology 161:127-138, 2000.
  54. Webster, S.D., Park, M., Fonseca, M.I. and Tenner, A.J.  Structural and functional evidence for microglial expression of C1qRP, the C1q receptor that enhances phagocytosis, J. Leuk. Biol. 67:109-116, 2000.
  55. Tenner, A.J. C1qRP, in The Complement Factsbook, edited by B. Morley and M.Walport, Academic Press, pg. 176-179, 2000.
  56. Huang, J., Kim, L.J., Mealey, R., Marsh, H.C., Zhang, Y., Tenner, A.J., Connolly, E.S., Pinsky, D. J. , Neuronal Protection in stroke by an sLex-glycosylated complement inhibitor protein.  Science 285: 595-599, 1999.
  57. Ruiz, S., Henschen-Edman, A. H., Nagase, H.  and Tenner, A.J.  Digestion of C1q collagen like domain with matrix metalloproteinases, MMP 1, 2, 3 and 9, further defines the sequence involved in the stimulation of neutrophil superoxide production, J. Leuk. Biol.  66:416-422, 1999.
  58. Tenner, A.J., Membrane receptors for soluble defense collagens.  Cur. Op. In Immunol. 11:34-41, 1999.
  59. Nepomuceno, R.R., Ruiz, S.,  Park, M. and Tenner,  A.J.  C1qRP is a Heavily O-glycosylated Cell Surface Protein Involved in the Regulation of Phagocytic Activity. J. Immunol. 162: 3583-3589, 1999.
  60. Webster, S.D., Tenner, A.J.,  Poulos, T.L. and Cribbs, D.H.,   Mouse C1q A-chain sequence alters β-amyloid-induced complement activation.  Neurobiology of Aging 20: 297-304,1999.
  61. Fonseca, M.I., Head, E. Velazquez, P., Cotman, C.W. and Tenner, A.J. The presence of isoaspartic acid in ß-amyloid plaques indicates plaque age.  Experimental Neurology  157:277-288, 1999.
  62. Eggleton, P., Reid, K.B.M., and  Tenner, A.J.  C1q, how many functions? How many receptors? Trends in Cell Biology 8: 428-43, 1998.
  63. Tenner, A.J. C1q Receptors: Regulating specific functions of phagocytic cells.  Immunobiology 199(2):250-264,  1998.   (Invited review).
  64. Nepomuceno, R.R. and Tenner, A.J.  C1qRP, the C1q Receptor That Enhances Phagocytosis, Is Detected Specifically in Human Cells of Myeloid Lineage, Endothelial Cells and Platelets.  J. Immunol. 160:1929-1935, 1998.
  65. He, X.-P., Patel, M., Whitney, K.D., Janumpalli, S. , Tenner, A., and McNamara,  J.O.  Glutamate Receptor GluR3 Antibodies and Death of Cortical Cells.  Neuron 20, 153 163, 1998.
  66. Cribbs, D.H.,Velazquez, P. ,Soreghan,  B. , Glabe,C.G.  and Tenner, A.J.  Complement activation by crosslinked truncated and chimeric full length β-amyloid.  Neuroreport 8: 3457-3462, 1997.
  67. Tenner, A.J. C1q Receptors: Opportunities for selectively regulating protective and detrimental responses.  Clin. Immunol. Newsletter 17:173-177, 1997  (Invited review).
  68. Webster,S., Lue,L.-F., Brachova, L., Tenner, A.J., McGeer, P.L., Terai, K., Walker, D., Bradt, B., Cooper, N.R., and Rogers, J.  Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer’s Disease. Neurobiology of Aging 18:415-421, 1997.
  69. Satou,T., Cummings, B.J., Head, E., Nielson, K.A., Hahn, F.F., Milgram, N.W., Velazquez, P., Cribbs, D.H., Tenner, A.J., and Cotman, C.W.  The progression of β-amyloid deposition in the frontal cortex of the aged canine.  Brain Research 774:35-43, 1997.
  70. King, P.J., McDougall, B.R., Tenner, A.J., and Robinson, W.E., Jr.  Amino acids 603-622 of Simian Immunodeficiency Virus transmembrane glycoprotein bind complement component C1q leading to deposition of complement component C3 and increased infectivity of cell lines expressing CD4 and CR2.  Pathogenesisis 1:43-56, 1997.
  71. Nepomuceno, R.R., Henschen-Edman, A.H., Burgess, W.H., and Tenner, A.J. cDNA cloning and primary structure analysis of C1qRP, the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro.  Immunity 6:119-129, 1997.
  72. Velazquez, P., Cribbs, D.H., Poulos, T.L. and Tenner, A.J.  Aspartate residue 7 in amyloid β-protein is critical for classical complement pathway activation: Implications for Alzheimer’s disease pathogenesis.  Nature Medicine 3:77-79, 1997.
  73. Cotman, C.W., Tenner, A.J. and Cummings, B.J.  β-Amyloid converts an acute phase injury response to chronic injury responses.  Neurobiology of Aging 17:723-731, 1996.
  74. Afagh, A., Cummings, B.J., Cribbs, D.H., Cotman, C.W. and Tenner, A.J.  Localization and cell association of C1q in Alzheimer’s Disease brain.  Exp. Neurology 138:22-32, 1996.
  75. Ruiz, S., Henschen-Edman, A. and Tenner, A.J. Localization of the site on the complement component C1q required for the stimulation of neutrophil superoxide production.  J. Biol. Chem. 270:30627-30634, 1995.
  76. Korotzer, A.R., Watt, J., Cribbs, D., Tenner, A.J., Burdick, D., Glabe, C., and Cotman, C.W.  Cultured rat microglia express C1q and receptor for C1q:  Implications for amyloid effects on microglia.  Exp. Neurology 134:214-221, 1995.
  77. Goodman, E.B., Anderson, D.C. and Tenner, A.J.  C1q triggers neutrophil superoxide production by a unique CD18-dependent mechanism.  J. Leukocyte Biology 58:168-176, 1995.
  78. Tenner, A.J., Robinson, S.L., and Ezekowitz, R.A.B. Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 Mr component of the C1q receptor.  Immunity 3: 485-494, 1995.
  79. Jiang, H., Burdick, D., Glabe, C.G., Cotman, C.W., and Tenner, A.J.  β-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.  J. Immunol. 152:5050-5059, 1994.
  80. Smyth, M.D., Cribbs, D.H., Tenner, A.J., Shankle, W.R., Dick, M., Kesslak, J.P. and Cotman, C.W.  Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state.  Neurobiology of Aging 15:609-614, 1994.
  81. Guan, E., Robinson, S.L., Goodman, E., and Tenner, A.J.  Cell surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis. J. Immunol., 152:4005-4016, 1994.
  82. Tenner, A.J. C1q Receptors:  Functional studies., in Behring Institute Mitteilungen, F.R. Seiler & H.G. Schwick, editors in chief., 93:241-253, 1993.
  83. Goodman, E.B. and Tenner, A.J.  Signal transduction mechanisms of C1q-mediated superoxide production:  Evidence for the involvement of temporally distinct staurosporine insensitive and sensitive phases.  J. of Immunol. 148:3920-3928, 1992.
  84. Guan, E., Burgess,W.H., Robinson, S.L., Goodman, E.B., McTigue, K.J., and Tenner, A.J. Phagocytic cell molecules that bind the collagen-like region of C1q: Involvement in the C1q-mediated enhancement of phagocytosis.  J. Biol. Chem. 266:20345-20355, 1991.
  85. Young, K.R., Ambrus, J.L.Jr., Malbran, A., Fauci, A.S. and Tenner, A.J.  Complement Subcomponent C1q stimulates immunoglobulin production by human B lymphocytes.  J. Immunol. 146:3356-3364, 1991.
  86. Schweinle, J.E., Ezekowitz, R.A.B., Tenner, A.J., Kuhlman, M., and Joiner, K.A. Human Mannose Binding Protein activates the alternative complement pathway and enhances serum bactericidal activity. J. Clin. Invest. 84:1821-1829, 1989.
  87. Tenner, A.J., Robinson, S., Borchelt, J., Wright, J.R.:  Human Pulmonary Surfactant Protein (SP A), a protein structurally homologous to C1q, can enhance  FcR  and CR1 mediated phagocytosis.  J. Biol. Chem. 264: 13923-13928, 1989.
  88. Rimoldi, M., Tenner, A.J., Bobak, D.A., and Joiner, K.A. Enhanced invasion of mononuclear phagocytes by serum treated Trypanosoma cruzi  is due to C1q.  J. Clin. Invest. 84:1982-1989, 1989.
  89. Tenner, A.J. C1q interactions with cell surface receptors. in Behring Institute Mitteilungen, F.R. Seiler & H.G. Schwick, editors in chief.  Nr. 84:220-235, 1989.
  90. Schweinle, J.E., Hitchcock, P.J., Tenner, A.J., Hammer, C.H., Frank, M.M. and Joiner, K.A.   Interaction of Neisseria gonorrhoeae with Classical Complement Components, C1 Inhibitor, and Monoclonal Antibody directed against the Neisserial H.8 Antigen.  J. Clin. Invest. 83:397  403, 1989.
  91. Ambrus, J.L., Jr., Goldstein, H., Young, K.R., McFarland, P., Nakagawa, T., Nakagawa, N., Brown, E., Uckun, F., Tenner, A.J., Peters, M., Witzel, N., Mostowski, H., Fauci, A.S.  Regulation of Human B Cell Function. Lymphocyte Activation and Differentiation.  J.C. Mani and J. Dornand, editors.  Walter De Gruyter & Co., Berlin. pp. 73 81, 1988.
  92. Bobak, D.A., Frank, M.M. and Tenner, A.J.  C1q acts synergistically with phorbol dibutyrate to activate CR1 mediated phagocytosis by human   mononuclear phagocytes.  Eur. J. of Immunol. 18:2001 2007, 1988.
  93. Bobak, D.A., Gaither, T.G., Frank, M.M., & Tenner, A.J.: Modulation of FcR Function by Complement:  Subcomponent C1q enhances the phagocytosis of IgG opsonized targets by human monocytes and culture derived macrophages. J.Immunol. 138:1150 1156, 1987.
  94. Bobak, D.A., Frank, M.M. & Tenner, A.J.:  Characterization of C1q receptor expression on human phagocytic cells: Effects of PDBu and fMLP. J. of Immunol.,  136:4604 4610, 1986.
  95. Tenner, A.J. & Frank, M.M.: Activator bound C1 is less susceptible to inactivation by its regulatory protein C1 Inhibitor than is fluid phase C1.  J. of Immunol. 137:625 630, 1986.
  96. Tenner, A.J. & Frank, M.M.:  A sensitive, specific hemolytic assay for proenzyme C1.  Complement, 4:42 52, 1987.
  97. Tenner, A.J. & Volkin, D.B.:  C1q secreted by cultured human monocytes has subunit structure identical to serum C1q. Biochemical Journal 233:451 458, 1986.
  98. Bohnsack, J.S., Tenner, A.J., Laurie, G.W., Kleinman, H.K., Martin, G.R. & Brown, E.J.:  C1q binds to laminin:  A mechanism for the deposition and retention of immune complexes in basement membrane. Proc. Natl. Acad. Sci.  80:3824 3828, 1985.
  99. Terkeltaub, R., Curtiss, L.K., Tenner, A.J. & Ginsberg, M.H.:  Lipoproteins containing apoprotein B are a major regulator of neutrophil responses to monosodium urate crystals. J. Clin. Invest. 73:1719 1730, 1984.
  100. Tenner, A.J., Ziccardi, R.J. & Cooper, N.R.:  Antibody independent C1 activation by E. coli.  J. Immunol.  133:886 891, 1984.
  101. Terkeltaub, R., Tenner, A.J., Kozin, F. & Ginsberg, M.H.:  Plasma protein binding by monosodium urate crystals. Arthr. & Rheum. 26:1091  1100, 1983.
  102. Tenner, A.J. & Cooper, N.R.:  Stimulation of a Human polymorphonuclear leukocyte oxidative response by the C1q subunit of the first complement component. J. Immunol.  128:2547 2552, 1982.
  103. Tenner, A.J., Lesavre, P.H. & Cooper, N.R.:  Purification and radiolabeling of human C1q. J. Immunol.  127:648 653, 1981.
  104. Tenner, A.J. & Cooper, N.R.: Identification of types of cells in human peripheral blood which bind C1q. J. Immunol. 126:1174 1179, 1981.
  105. Tenner, A.J. & Cooper, N.R.:  Analysis of receptor mediated C1q binding to human peripheral blood mononuclear cells. J. Immunol. 125:1658 1664, 1980.
  106. Tenner, A.J. &  Scheffler, I.E.:  Lipid saccharide  intermediates  and glycoprotein biosynthesis in a temperature sensitive Chinese hamster cell mutant. J. Cell. Physiol.  98:251 265, 1979.
  107. Tenner, A., Zieg, J.& Scheffler, I.E.: Glycoprotein synthesis in a temperature sensitive cell cycle mutant. J. Cell. Physiol.  90:145 160, 1977.
  108. Chrispeels, M.J., Tenner, A.J. & Johnson, K.D.:  Synthesis and release of  sucrose by the aleurone layer of barley.  Planta 113:35 46, 1973.
  109. Tenner, A.J. & Wallace, R.A.:  A cyclic AMP stimulated protein kinase from amphibian ovary and oocytes.Biochem. et Biophys. Acta 276:416-424, 1972.